Effects of Compound 48/80 and Formyl-Methionyl-Leucyl-Phenylalanine on Isolated Guinea Pig Airways
Bibliographic record
Abstract
Compound 48/80 and formyl-methionyl-leucyl-phenylalanine (fMLP), but not concanavalin A and dextran, contract isolated guinea pig tracheal spirals and lung parenchymal strips. fMLP induced a brief histamine-independent contraction of parenchymal strips. Tracheal contraction by fMLP was only observed in the presence of indomethacin, suggesting the involvement of a bronchoconstrictor lipoxygenase product of arachidonic acid (AA). Contractions induced by compound 48/80 were prolonged, were not dependent on extracellular calcium and were partly inhibited in the first 10 min by mepyramine, and after this by phenidone. Indomethacin enhanced contractions of trachea but inhibited contractions of parenchyma. Thus, histamine only contributes to the early part of compound 48/80-induced airway contractions, and lipoxygenase-derived AA products contribute after that. Bronchoconstrictor cyclooxygenase products may also contribute to parenchymal contractions. Compound 48/80 contracts the airways in a similar manner to antigen and thus may provide a useful model to examine mediator release and airway smooth muscle contraction.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".