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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt, Stefan Gustafsson, Reedik Mägi, Andrea Ganna, Eleanor Wheeler, Mary F. Feitosa, Anne E. Justice, Keri L. Monda, Damien C. Croteau‐Chonka, Felix R. Day, Tõnu Esko, Tove Fall, Teresa Ferreira, Davide Gentilini, Anne Jackson, Jian’an Luan, Joshua C. Randall, Sailaja Vedantam, Cristen J. Willer, Thomas W. Winkler, Andrew R. Wood, Tsegaselassie Workalemahu, Yi‐Juan Hu, Sang Lee, Liming Liang, Dan-Yu Lin, Josine L. Min, Benjamin M. Neale, Guðmar Þorleifsson, Jian Yang, Eva Albrecht, Najaf Amin, Jennifer L. Bragg‐Gresham, Gemma Cadby, Martin den Heijer, Niina Eklund, Krista Fischer, Anuj Goel, Jouke‐Jan Hottenga, Jennifer E. Huffman, Ivonne Jarick, Åsa Johansson, Toby Johnson, Stavroula Kanoni, Marcus E. Kleber, Inke R. König, Kati Kristiansson, Zoltán Kutalik, Claudia Lamina, Cécile Lecœur, Li Guo, Massimo Mangino, Wendy L. McArdle, Carolina Medina‐Gómez, Martina Müller‐Nurasyid, Julius S. Ngwa, Ilja M. Nolte, Lavinia Paternoster, Sonali Pechlivanis, Markus Perola, Marjolein J. Peters, Michael Preuß, Lynda M. Rose, Jianxin Shi, Dmitry Shungin, Albert V. Smith, Rona J. Strawbridge, Ida Surakka, Alexander Teumer, Mieke D. Trip, Jonathan P. Tyrer, Jana V. van Vliet‐Ostaptchouk, Liesbeth Vandenput, Lindsay L. Waite, Wei Zhao, Devin Absher, Folkert W. Asselbergs, Mustafa Atalay, Antony Attwood, Anthony J. Balmforth, Hanneke Basart, John Beilby, Lori L. Bonnycastle, Paolo Brambilla, Marcel Bruinenberg, Harry Campbell, Daniel I. Chasman, Peter S. Chines, Francis S. Collins, John Connell, William Cookson, Ulf dé Fairé, Femmie de Vegt, Mariano Dei, Maria Dimitriou, Sarah Edkins, Karol Estrada, David M. Evans, Martin Farrall, Maurizio Ferrario, Jean Ferrières, Lude Franke, Francesca Frau, Pablo V. Gejman, Harald Grallert, Henrik Grönberg, Vilmundur Guðnason, Alistair S. Hall, Per Hall, Anna‐Liisa Hartikainen, Caroline Hayward, Nancy L. Heard‐Costa, Andrew C. Heath, Johannes Hebebrand, Georg Homuth, Frank B. Hu, Sarah Hunt, Elina Hyppönen, Carlos Iribarren, Kevin B. Jacobs, John‐Olov Jansson, Antti Jula, Mika Kähönen, Sekar Kathiresan, Frank Kee, Kay‐Tee Khaw, Mika Kivimäki, Wolfgang Köenig, Aldi T. Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Jaana Laitinen, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Lars Lind, Jaana Lindström, Jianjun Liu, Antonio Liuzzi, Marja‐Liisa Lokki, Mattias Lorentzon, Pamela A. F. Madden, Patrik K. E. Magnusson, Paolo Manunta, Diana Marek, Winfried März, Irene Mateo Leach, Barbara McKnight, Sarah E. Medland, Evelin Mihailov, Lili Milani, Grant W. Montgomery, Vincent Mooser, Patricia B. Munroe, Arthur W. Musk, Narisu Narisu, Gerjan Navis, Ellen A. Nøhr, Ken K. Ong, Ben A. Oostra, Aarno Palotie, John F. Peden, Nancy L. Pedersen, Annette Peters, Ozren Polašek, Anneli Pouta, Peter P. Pramstaller, Inga Prokopenko, Carolin Pütter, Aparna Radhakrishnan, Olli Raitakari, Augusto Rendon, Fernando Rivadeneira, Igor Rudan, Timo Saaristo, Jennifer G. Sambrook, Alan R. Sanders, Serena Sanna, Jouko Saramies, Sabine Schipf, Stefan Schreiber, Heribert Schunkert, So–Youn Shin, Stefano Signorini, Juha Sinisalo, Boris Skrobek, Nicole Soranzo, Alena Stančáková, Klaus Stark, Jonathan Stephens, Kathleen Stirrups, Ronald P. Stolk, Michael Stümvoll, Amy J. Swift, Eirini Theodoraki, Barbara Thorand, David‐Alexandre Trégouët, Elena Tremoli, Melanie M. van der Klauw, Joyce B. J. van Meurs, Sita H. Vermeulen, Jorma Viikari, Jarmo Virtamo, Véronique Vitart, Gérard Waeber, Elisabeth Widén, Sarah H. Wild, Gonneke Willemsen, Bernhard R. Winkelmann, Jacqueline C.M. Witteman, Bruce H. R. Wolffenbuttel, Andrew Wong, Alan F. Wright, M. Carola Zillikens, Philippe Amouyel, Bernhard O. Boehm, Eric Boerwinkle, Dorret I. Boomsma, Mark J. Caulfield, Stephen J. Chanock, L. Adrienne Cupples, Daniele Cusi, George Dedoussis, Jeanette Erdmann, Johan G. Eriksson, Paul W. Franks, Philippe Froguel, Christian Gieger, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Christian Hengstenberg, Andrew A. Hicks, Aroon D. Hingorani, Anke Hinney, Albert Hofman, Kees Hovingh, Kristian Hveem, Thomas Illig, Marjo‐Riitta Järvelin, Karl‐Heinz Jöckel, Sirkka Keinänen‐Kiukaanniemi, Lambertus A. Kiemeney, Diana Kuh, Markku Laakso, Terho Lehtimäki, Douglas F. Levinson, Nicholas G. Martin, Andres Metspalu, Andrew D. Morris, Markku S. Nieminen, Inger Njølstad, Claes Ohlsson, Albertine J. Oldehinkel, Willem H. Ouwehand, Lyle J. Palmer, Brenda W.J.H. Penninx, Chris Power, Michael A. Province, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Paul M. Ridker, Samuli Ripatti, Veikko Salomaa, Nilesh J. Samani, Harold Snieder, Thorkild I. A. Sørensen, Timothy D. Spector, Kāri Stefánsson, Anke Tönjes, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Péter Vollenweider, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, H-Erich Wichmann, James F. Wilson, Gonçalo R. Abecasis, Themistocles L. Assimes, Inês Barroso, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Timothy M. Frayling, Talin Haritunian, Iris M. Heid, David J. Hunter, Robert C. Kaplan, Fredrik Karpe, Miriam F. Moffatt, Karen L. Mohlke, Jeffrey R. O’Connell, Yudi Pawitan, Eric E. Schadt, David Schlessinger, Valgerður Steinthórsdóttir, David P. Strachan, Unnur Þorsteinsdóttir, Cornelia M. van Duijn, Peter M. Visscher, Anna Maria Di Blasio, Joel N. Hirschhorn, Cecilia M. Lindgren, Andrew P. Morris, David Meyre, André Scherag, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, Ruth J. F. Loos, Erik Ingelsson
Bibliographic record
VenueNature Genetics · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsLunenfeld-Tanenbaum Research InstituteMcMaster UniversityOntario Institute for Cancer Research
FundersNational Cancer InstituteNational Human Genome Research InstituteNational Heart, Lung, and Blood InstituteAustralian Research CouncilEconomic and Social Research CouncilNational Institutes of HealthHeinz Nixdorf StiftungProvincia autonoma di Bolzano - Alto AdigeDiabetestutkimussäätiöHjartaverndNovo Nordisk FondenPaavo Nurmen SäätiöMedical Research CouncilTartu ÜlikoolSvenska KulturfondenOrionin TutkimussäätiöGöteborgs LäkaresällskapSydäntutkimussäätiöSamfundet FolkhälsanEmil Aaltosen SäätiöVetenskapsrådetNational Institute on Alcohol Abuse and AlcoholismStockholms Läns LandstingPäivikki ja Sakari Sohlbergin SäätiöCentre for Medical Systems BiologyNovo NordiskMinistero della SaluteNational Institute of Diabetes and Digestive and Kidney DiseasesTurun Yliopistollinen KeskussairaalaKnut och Alice Wallenbergs StiftelseNational Institute of General Medical SciencesNational Alliance for Research on Schizophrenia and DepressionNierstichtingBritish Heart FoundationBundesministerium für Bildung und ForschungEuropean Regional Development FundTerveyden ja hyvinvoinnin laitosAcademy of FinlandErasmus Medisch CentrumVrije Universiteit AmsterdamStiftelsen för Strategisk ForskningUniversitair Medisch Centrum GroningenDiabetes FondsNational Science FoundationFondation LeducqAgence Nationale de la RechercheHjärt-LungfondenRoyal SocietyAgency for Science, Technology and ResearchHelmholtz Zentrum MünchenMarch of Dimes FoundationKelaSvenska LäkaresällskapetDeutsche ForschungsgemeinschaftEuropean Science FoundationFondation pour la Recherche MédicaleSvenska Sällskapet för Medicinsk ForskningSocialdepartementetEuropean CommissionNHS Blood and TransplantFolkhälsanin TutkimussäätiöNational Institute for Health and Care ResearchWellcome TrustCancer Research UKMinistero dell’Istruzione, dell’Università e della RicercaQIMR Berghofer Medical Research InstituteScottish GovernmentYrjö Jahnssonin SäätiöCancerfondenFinska LäkaresällskapetFoundation for Cardiovascular ResearchDivision of Cancer Epidemiology and Genetics, National Cancer InstituteJuvenile Diabetes Research Foundation InternationalSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungTampereen TuberkuloosisäätiöRijksuniversiteit GroningenTorsten Söderbergs StiftelseKarolinska InstitutetNational Health and Medical Research CouncilSuomen KulttuurirahastoCedars-Sinai Medical CenterSigne ja Ane Gyllenbergin SäätiöGlaxoSmithKlineDonald W. Reynolds FoundationJuho Vainion SäätiöSusan G. Komen for the Cure
KeywordsBiologyGenetic architectureGeneticsGenome-wide association studyGenomeComputational biologyQuantitative trait locusMeta-analysisEvolutionary biologyGeneGenotypeSingle-nucleotide polymorphism
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.033
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.008 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.008 |
| Bibliometrics | 0.004 | 0.007 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.017
GPT teacher head0.278
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
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Citations687
Published2013
Admission routes1
Has abstractno