Physical Stability and Lyophilization of Poly(<i>ε</i>-caprolactone)-b-Poly(ethyleneglycol)-b-Poly(<i>ε</i>-caprolactone) Micelles
Bibliographic record
Abstract
The stability and lyophilization of core-shell PCL-PEG-PCL micelles were investigated by fluorescence spectra, DLS, DSC, WAXD, and FT-IR. The prepared micelles were not stable when they were stored in aqueous dispersion under different condition. Their size increased in the first 20 days and decreased gradually when the storage period was extended. Lyophilization experiment showed that the cryoprotective agent (glucose) was an essential additive to protect the micelles from aggregating during the lyophilization process. After lyophilizing and re-dispersion, the PCL-PEG-PCL micelles became larger in size compared to as-prepared ones. DSC, WAXD, and IR measurements indicated the hydrogen bonding was formed between the hydroxyl group in glucose and the carbonyl group in PCL-PEG-PCL micelles. The effect of added glucose on protection of micelles from aggregation can be explained by the formation of hydrogen bonding with PCL-PEG-PCL micelles and the formation of solid glucose matrix.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".