Pars Intermedia and Pars Distalis:Two Sites of ACTH Production in the Rat Hypophysis
Bibliographic record
Abstract
Pars intermedia and pars distalis of the rat hypophysis were examined, following experimentally induced alterations in ACTH secretion. The concentration of ACTH in the pars inter-media is considerably greater than that in the pars distalis. At 1 month after adrenalectomy, the ACTH concentration in the pars distalis increased 3-fold, while that in the pars intermedia remained unchanged. Following chronic administration of cortisol, the ACTH concentration in the pars distalis fell to 27% of the control, while the fall in ACTH concentration in the pars intermedia was not significant. The immunoglobulin-peroxidase bridge technique, employing 17–39 ACTH antiserum, demonstrated the presence of ACTH-containing cells, both in the pars intermedia and in the pars distalis. Following adrenalectomy or chronic administration of cortisol, there was no change in the immunostaining or in the electron microscopic appearance of the cells of the pars intermedia. These findings suggest that although a relation between the pars intermedia and ACTH is established, this relation is different from that between the pars distalis and ACTH.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".