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Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed, Mark Eijgelsheim, Tõnu Esko, Bianca J.J.M. Brundel, David S. Peal, David M. Evans, Ilja M. Nolte, Ayellet V. Segrè, Hilma Hólm, Robert E. Handsaker, Harm-Jan Westra, Toby Johnson, Aaron Isaacs, Jian Yang, Alicia Lundby, Jing Zhao, Young Jin Kim, Min Jin Go, Peter Almgren, Murielle Bochud, Gabrielle Boucher, Marilyn C. Cornelis, Daníel F. Guðbjartsson, David Hadley, Pim van der Harst, Caroline Hayward, Martin den Heijer, Wilmar Igl, Anne Jackson, Zoltán Kutalik, Jian’an Luan, John P. Kemp, Kati Kristiansson, Claes Ladenvall, Mattias Lorentzon, May E. Montasser, Omer T. Njajou, Paul F. O’Reilly, Sandosh Padmanabhan, Beaté St Pourcain, Tuomo Rankinen, Perttu Salo, Toshiko Tanaka, Nicholas J. Timpson, Véronique Vitart, Lindsay L. Waite, William Wheeler, Weihua Zhang, Harmen H. M. Draisma, Mary F. Feitosa, Kathleen F. Kerr, Penelope A. Lind, Evelin Mihailov, N. Charlotte Onland‐Moret, Ci Song, Michael N. Weedon, Weijia Xie, Loïc Yengo, Devin Absher, Christine M. Albert, Álvaro Alonso, Dan E. Arking, Paul I. W. de Bakker, Beverley Balkau, Cristina Barlassina, Paola Benaglio, Nabila Bouatia‐Naji, Søren Brage, Stephen J. Chanock, Peter S. Chines, Mina K. Chung, Dawood Darbar, Christian Dina, Marcus Dörr, Paul Elliott, Stephan B. Felix, Krista Fischer, Christian Fuchsberger, Eco J. C. de Geus, Philippe Goyette, Vilmundur Guðnason, Tamara B. Harris, Anna‐Liisa Hartikainen, Aki S. Havulinna, Susan R. Heckbert, Andrew A. Hicks, Albert Hofman, Suzanne Holewijn, Femke Hoogstra‐Berends, Jouke‐Jan Hottenga, Majken K. Jensen, Åsa Johansson, Juhani Junttila, Stefan Kääb, Bart Kanon, Shamika Ketkar, Kay‐Tee Khaw, Joshua W. Knowles, Angrad S Kooner, Jan A. Kors, Meena Kumari, Lili Milani, Päivi Laiho, Edward G. Lakatta, Claudia Langenberg, Maarten Leusink, Ching‐Ti Liu, Robert Luben, Kathryn L. Lunetta, Stacey N. Lynch, Marcello Ricardo Paulista Markus, Pedro Marques‐Vidal, Irene Mateo Leach, Wendy L. McArdle, Steven A. McCarroll, Sarah E. Medland, Kathryn Miller, Grant W. Montgomery, Alanna C. Morrison, Martina Müller‐Nurasyid, Pau Navarro, Mari Nelis, Jeffrey R. O’Connell, Christopher J. O’Donnell, Ken K. Ong, Anne B. Newman, Annette Peters, Ozren Polašek, Anneli Pouta, Peter P. Pramstaller, Bruce M. Psaty, D. C. Rao, Susan M. Ring, Elizabeth J. Rossin, Diana Rudan, Serena Sanna, Robert A. Scott, Jaban S Sehmi, Stephen J. Sharp, Jordan T. Shin, Andrew Singleton, Albert V. Smith, Nicole Soranzo, Tim D. Spector, Chip Stewart, Heather M. Stringham, Kirill V. Tarasov, André G. Uitterlinden, Liesbeth Vandenput, Shih‐Jen Hwang, John B. Whitfield, Cisca Wijmenga, Sarah H. Wild, Gonneke Willemsen, James F. Wilson, Jacqueline C.M. Witteman, Andrew Wong, Quenna Wong, Yalda Jamshidi, Paavo Zitting, Jolanda M.A. Boer, Dorret I. Boomsma, Ingrid B. Borecki, Cornelia M. van Duijn, Ulf Ekelund, Nita G. Forouhi, Philippe Froguel, Aroon D. Hingorani, Erik Ingelsson, Mika Kivimäki, Richard A. Kronmal, Diana Kuh, Lars Lind, Nicholas G. Martin, Ben A. Oostra, Nancy L. Pedersen, Thomas Quertermous, Jerome I. Rotter, Yvonne T. van der Schouw, W. M. Monique Verschuren, Mark Walker, Demetrius Albanes, Davíð O. Arnar, Themistocles L. Assimes, Stefania Bandinelli, Michael Boehnke, Rudolf A. de Boer, Claude Bouchard, Wilson Caulfield, John C. Chambers, Gary C. Curhan, Daniele Cusi, Johan G. Eriksson, Luigi Ferrucci, Wiek H. van Gilst, Nicola Glorioso, Jacqueline de Graaf, Leif Groop, Ulf Gyllensten, Wen-Chi Hsueh, Frank B. Hu, Heikki V. Huikuri, David J. Hunter, Carlos Iribarren, Bo Isomaa, Marjo‐Riitta Järvelin, Antti Jula, Mika Kähönen, Lambertus A. Kiemeney, Melanie M. van der Klauw, Jaspal S. Kooner, Peter Kraft, Licia Iacoviello, Terho Lehtimäki, Marja‐Liisa Lokki, Braxton D. Mitchell, Gerjan Navis, Markku S. Nieminen, Claes Ohlsson, Neil R Poulter, Lu Qi, Olli T. Raitakari, Eric B. Rimm, John D. Rioux, Federica Rizzi, Igor Rudan, Veikko Salomaa, Peter Sever, Denis C. Shields, Alan R. Shuldiner, Juha Sinisalo, Alice Stanton, Ronald P. Stolk, David P. Strachan, Jean‐Claude Tardif, Unnur Þorsteinsdóttir, Jaako Tuomilehto, Dirk J. van Veldhuisen, Jarmo Virtamo, Jorma Viikari, Péter Vollenweider, Gérard Waeber, Elisabeth Widén, Yoon Shin Cho, Jesper V. Olsen, Peter M. Visscher, Cristen J. Willer, Lude Franke, Jeanette Erdmann, J. Thompson, Arne Pfeufer, Nona Sotoodehnia, Christopher Newton‐Cheh, Patrick T. Ellinor, Bruno H. Stricker, Andres Metspalu, Markus Perola, J. Beckmann, George Davey Smith, Kāri Stefánsson, Nicholas J. Wareham, Patricia B. Munroe, Ody C.M. Sibon, David J. Milan, Harold Snieder, Nilesh J. Samani, Ruth J. F. Loos
Bibliographic record
VenueNature Genetics · 2013
Typereview
Languageen
FieldMedicine
TopicHeart Rate Variability and Autonomic Control
Canadian institutionsUniversité de MontréalMontreal Heart Institute
FundersNational Center for Advancing Translational SciencesNational Institute on Drug AbuseNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteEconomic and Social Research CouncilNovo Nordisk FondenNational Institute of General Medical SciencesMedical Research CouncilNational Institute for Health and Care ResearchBritish Heart FoundationWellcome Trust
KeywordsBiologyIdentification (biology)RhythmHeart RhythmGeneticsInternal medicineComputational biologyNeuroscienceMedicineEcology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.011
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.013
GPT teacher head0.288
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designSystematic review
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations320
Published2013
Admission routes1
Has abstractno