Hypersensitivity of Inner Medullary Collecting Duct Cells to Arginine Vasopressin and Forskolin in Cardiomyopathic Hamsters
Bibliographic record
Abstract
Circulating arginine vasopressin (AVP) levels are elevated in congestive heart failure (CHF). However, the second messenger changes of the AVP system in CHF have not been explored. The aim of the present study is to determine whether there are changes in cAMP production in the AVP system in CHF. Cardiomyopathic hamsters of strain UM-X7.1 were used. Normal Golden Syrian hamsters were used as controls. IMCD cells were isolated from both group of hamsters. cAMP accumulation experiments were performed with AVP and forskolin stimulation in vitro. There was more cAMP release after stimulation by both AVP and forskolin in the cardiomyopathic than normal hamster IMCD cells. This illustrates that hypersensitivity of IMCD cells to AVP exists in cardiomyopathic hamsters. This may be partly explained by the presence of V2 receptor adenylate cyclase hyperactivity. The hypersensitivity of IMCD cells to AVP may be one of the factors causing fluid retention in CHF.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".