Developments in mitogen-induced extracellular kinase 1 inhibitors and their use in the treatment of disease
Bibliographic record
Abstract
Multiple signal transduction pathways converge on the Raf-mitogen-induced extracellular kinase (MEK)-extracellular signal-regulated kinase (Erk) cascade to effect diverse cellular processes, including proliferation, differentiation, survival, apoptosis and organ functions such as memory consolidation. Improper activation of this pathway contributes significantly to numerous diseases, including cancer and various immune disorders. Specific inhibition of this signalling cascade thus offers great therapeutic potential for many diseases. Since the discovery of the first MEK1 inhibitor in 1995, several novel classes of inhibitors, with varying selectivity for MEK1, have been developed. Clinical applications for some of these have been investigated, with the majority focusing on proliferative diseases in which abnormally increased Erk activity plays a major role, most notably cancer, or immunological and inflammatory conditions such as arthritis and organ transplant rejection. To a lesser extent, ischaemia/reperfusion (I/R) injury and chronic pain disorders have also been targeted.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".