Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
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- Teacher spread
- 0.223 · how far apart the two teachers sit on this one work
- Validation status
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Abstract
In the standard model of pavlovian fear learning, sensory input from neutral and aversive stimuli converge in the lateral nucleus of the amygdala (LA), in which alterations in synaptic transmission encode the association. During fear expression, the LA is thought to engage the central nucleus of the amygdala (CE), which serves as the principal output nucleus for the expression of conditioned fear responses. In the present study, we reexamined the roles of LA and CE. Specifically, we asked whether CE, like LA, might also be involved in fear learning and memory consolidation. Using functional inactivation methods, we first show that CE is involved not only in the expression but also the acquisition of fear conditioning. Next, we show that inhibition of protein synthesis in CE after training impairs fear memory consolidation. These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning.
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The record
- Venue
- Journal of Neuroscience
- Topic
- Memory and Neural Mechanisms
- Field
- Neuroscience
- Canadian institutions
- —
- Funders
- National Institute of Mental HealthYork UniversityW. M. Keck Foundation
- Keywords
- Fear conditioningAmygdalaFear processing in the brainNeurosciencePsychologyMemory consolidationClassical conditioningNucleusConsolidation (business)Extinction (optical mineralogy)Central nucleus of the amygdalaConditioningHippocampusBiology
- Has abstract in OpenAlex
- yes