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Record W1993878690 · doi:10.1159/000214645

Factor IX Levels during Pregnancy in a Woman with Hemophilia B

2009· article· en· W1993878690 on OpenAlex
Ernest Briët, Howard M. Reisner, Philip M. Blatt

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueHaemostasis · 2009
Typearticle
Languageen
FieldMedicine
TopicHemophilia Treatment and Research
Canadian institutionsnot available
FundersNational Institutes of HealthProvincial Health Services Authority
KeywordsFactor IXPregnancyMedicinePlasmapheresisCoagulopathyVon Willebrand factorObstetricsGynecologyInternal medicineImmunologyPlateletAntibody

Abstract

fetched live from OpenAlex

The levels of factors VIII, II, and VII rise during pregnancy in normal women. In addition, increases in factor VIII levels have been observed in pregnant carriers of hemophilia A and in women affected with von Willebrand's disease. The influence of pregnancy on factor IX levels is less clear. Consequently, we determined serial factor IX coagulant activities (IX:C) and factor IX antigen levels (IX:Ag) during the pregnancy of an affected carrier of hemophilia B who had baseline values of 13% both IX:C and IX:Ag levels. Neither level rose during pregnancy and the patient was treated with plasmapheresis and plasma infusions during the delivery and the postpartum period. Excessive bleeding did not occur.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.573
Threshold uncertainty score0.525

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.325
Teacher spread0.268 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it