High sodium intake stimulates endogenous sodium pump inhibitor, marinobufagenin, and increases blood pressure in pregnant rats
Bibliographic record
Abstract
Previous studies have implicated endogenous digitalis-like sodium pump ligands in pathogenesis of preeclampsia. Recently, we have shown that an endogenous bufadienolide, marinobufagenin (MBG), an inhibitor of ouabain resistant alpha-1 Na/K-ATPase, rather than endogenous ouabain (EO) becomes elevated and contributes to hypertension in patients with preeclampsia (Lopatin et al, J Hypertens 1999; 17: 1179-87) and in Dahl-S rats on a high NaCl intake (Fedorova et al, Circulation 2002; 105: 1122-27). We hypothesized that in pregnant rats on a high NaCl intake MBG increases and contributes to blood pressure (BP) elevation. Renal excretion of MBG, EO and sodium, systolic BP, and plasma renin activity (PRA) were compared in non-pregnant and pregnant Sprague-Dawley rats (225-250 g) during last week of pregnancy. Pregnant animal consumed either water or NaCl solution, 0.9% or 1.8%. As compared with non-pregnant rats, last week of pregnancy was associated with decreased systolic BP, increased PRA and moderate increases in renal excretion of MBG and EO. NaCl supplementation induced graded increases in renal Na excretion, in systolic BP and renal excretion of MBG and with concomitant decrease in PRA (Table). Supplementation with 1.8% NaCl was also associated with fetal growth retardation. Our results demonstrate that in rats NaCl supplementation during the last week of pregnancy induces preeclampsia-like symptoms including elevation of BP, proteinuria, suppression of PRA and fetal growth retardation. Elevations of BP are associated with enhanced excretion of MBG, which makes MBG a potential target for therapy. One-way ANOVA followed by Newman-Keuls test. -P<0.05, -P<0.01 vs. nonpregnant rats; -P<0.05, -P<0.01 vs. pregnant rats without NaCl supplementation. n=12–15 for each group. One-way ANOVA followed by Newman-Keuls test. -P<0.05, -P<0.01 vs. nonpregnant rats; -P<0.05, -P<0.01 vs. pregnant rats without NaCl supplementation. n=12–15 for each group.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".