Morphine Treatment during Rat Pregnancy: Neonatal and Preweaning Consequences
Bibliographic record
Abstract
Morphine treatment during pregnancy was scheduled with the view to reproduce physical dependence in female rats and to investigate the occurrence of a neonatal withdrawal syndrome (NWS) as well as more prolonged effects of the narcotic in the preweaned pups. Administration started 5 days prior to mating with the daily dose of 20 mg/kg i.p. injections. All along gestation, the dosage was gradually increased up to the final dose of 56 mg/kg/day on the 16th day when the treatment was interrupted. Pregnant dams showed behavioral manifestations of narcotic dependence and drug abstinence. At birth, morphine-exposed neonates exhibited (1) an approximate 28% decrease in respiratory rates (p less than 0.001) during the first day of life and (2) excessive crying (p less than 0.001) accompanied by restlessness. These two last features are related to clinical signs of the NWS identified in babies born to narcotic-addicted women. A significant delay in the time of eye-opening and an earlier sexual maturation in females only were also found in the postnatally developing morphine offsprings. The NWS and some other developmental changes were considered in relation to the used animal model and to possible processes involved in narcotic interferences with postnatal physical growth and neurobehavioral maturation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".