Mast Cell Heterogeneity: Effect of Anti-Allergic Compounds on Neuropeptide-Induced Histamine Release
Bibliographic record
Abstract
Increasing evidence suggests that neuropeptides may be important stimuli for mast cell secretion. Neuropeptide-induced histamine secretion from rat mast cells was inhibited by a variety of clinical and experimental antiallergic agents. The profile of responsiveness to this panel of drugs exhibited by peritoneal (PMC) and intestinal mucosal mast cells (IMC) was similar to that previously reported when histamine release was immunologically induced. Thus, cromoglycate, theophylline and Ro 22-3747 inhibited peptide-induced secretion from PMC but not from IMC. In contrast, doxantrazole was effective against PMC and IMC. Differences between IMC and PMC could not be attributed to the IMC isolation procedure. The results confirm the heterogeneity of responsiveness to antiallergic drugs exhibited by these mast cell subpopulations and indicate that it is not limited to immunologically induced secretion but also occurs when a neuropeptide is the secretory stimulus.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".