Signal Transduction by the TGF-β Superfamily
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- Teacher spread
- 0.275 · how far apart the two teachers sit on this one work
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Abstract
Transforming growth factor-beta (TGF-beta) superfamily members regulate a plethora of developmental processes, and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension. Intense investigations have revealed that SMAD proteins constitute the basic components of the core intracellular signaling cascade and that SMADs function by carrying signals from the cell surface directly to the nucleus. Recent insights have revealed how SMAD proteins themselves are regulated and how appropriate subcellular localization of SMADs and TGF-beta transmembrane receptors is controlled. Current research efforts investigating the contribution of SMAD-independent pathways promise to reveal advances to enhance our understanding of the signaling cascade.
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The record
- Venue
- Science
- Topic
- TGF-β signaling in diseases
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Lunenfeld-Tanenbaum Research InstituteUniversity of TorontoMount Sinai Hospital
- Funders
- —
- Keywords
- SMADR-SMADSignal transductionCell biologyTransforming growth factorBiologyTransmembrane proteinTransforming growth factor betaReceptorIntracellularTGF beta signaling pathwayCell surface receptorACVRL1EndoglinTGF alphaGeneticsGrowth factor
- Has abstract in OpenAlex
- yes