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Age-Dependent Phenotypic Clinical Expression of Crohn??s Disease

2005· article· en· W1995787398 on OpenAlexaff
Hugh James Freeman

Bibliographic record

VenueJournal of Clinical Gastroenterology · 2005
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMedicineDiseaseClinical phenotypeCrohn's diseaseGastrointestinal tractPhenotypeAge of onsetGastroenterologyInternal medicineGenetics

Abstract

fetched live from OpenAlex

Crohn's disease is a heterogeneous disorder that involves different sites along the length of the gastrointestinal tract. It is usually characterized by a high rate of strictures and penetrating complications. The present study used the modified Vienna classification schema to explore the specific role of age at diagnosis on both disease location and disease behavior. There were 1,015 consecutively evaluated patients, including 449 males and 566 females. Disease was most often localized in the ileocolon and could be most often classified as complex disease (ie, in >70%) with strictures or penetrating complications. For both males and females, with increasing age at diagnosis, disease became less extensive, more often localized in the colon alone, and disease behavior could be characterized as more complex, especially with penetrating disease complications. These results demonstrate the phenomenon of age dependence in the phenotypic clinical expression of Crohn's disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.350
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations31
Published2005
Admission routes1
Has abstractyes

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