Effect of ACE gene I/D polymorphism on hypertension-related traits in french-canadian families
Bibliographic record
Abstract
Angiotensin-converting enzyme (ACE) gene is a well known blood pressure candidate gene as demonstrated by previous studies, where its insertion/deletion (I/D) polymorphism has been shown to be associated with hypertension and coronary artery disease, and plasma ACE concentrations have been found to be associated with plasma triglyceride and total cholesterol levels. The aim of this study was to determine the effect of the I/D polymorphism on hypertension-related traits in French-Canadian families. 125 French-Canadian families were selected on the basis of having at least one sib pair affected by early-onset (<55 years) hypertension and dislipidemia. From these, 542 individuals were genotyped for I/D marker and a sib pair linkage analysis (SIBPAL, from S.A.G.E. package) adapted to familial structures was performed for seventy hypertension-related traits. In this population, allelic frequency was: allele I = 42.5%, allele D = 57.5%. The genotypic distribution was: I/I = 17.7%, I/D = 49.6% and D/D = 32.7%. The linkage analysis was significant for NaLi countertransport (p=0.03) in male sib pairs, for plasma levels of vasopressin (p=0.002) and of glucose (p=0.007) in female sib pairs and of ANP (p=0.003) in mixte sib pairs. Microalbumin excretion (p=0.037) was significantly linked in hypertensive sib pairs, whereas volume of total body water (p=0.005) and of intracellular water (p=0.012) correlated with the marker in normotensive sib pairs. No significative effect of the Ace locus was found for the systolic or diastolic blood pressures, left ventricular hypertrophy, wake or sleep heart rates, BMI, cholesterol or triglyceride levels in neither hypertensive nor normotensive gender specific groups. In French-Canadian population, the effect of Ace gene I/D marker on hypertension-related traits varies depending on hypertension status and gender. Results of the present genetic study underline the importance of Ace locus in the pathogenesis of hypertension, with a distinct effect on some previously suggested linkages.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".