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Record W1996305237 · doi:10.1016/j.jaci.2014.06.015

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

2014· review· en· W1996305237 on OpenAlexafffund
Stuart E. Turvey, Anne Durandy, Alain Fischer, Shan‐Yu Fung, Raif S. Geha, Andreas Gewies, Thomas Giese, Johann Greil, Bärbel Keller, Margaret L. McKinnon, Bénédicte Neven, Jacob Rozmus, Jürgen Ruland, Andrew L. Snow, Polina Stepensky, Klaus Warnatz

Bibliographic record

VenueJournal of Allergy and Clinical Immunology · 2014
Typereview
Languageen
FieldImmunology and Microbiology
TopicImmune Cell Function and Interaction
Canadian institutionsChild and Family Research InstituteBC Children's HospitalUniversity of British Columbia
FundersUCB PharmaNational Institute of Allergy and Infectious DiseasesCanadian Institutes of Health ResearchNovartis PharmaNational Institutes of HealthBritish Heart FoundationDeutsches Zentrum für InfektionsforschungEuropean CommissionPfizerGlaxoSmithKlineDeutsche ForschungsgemeinschaftConcern FoundationCSL BehringBundesministerium für Bildung und ForschungMichael Smith Health Research BCConquer Cancer Foundation
KeywordsBCL10ImmunodeficiencyBiologyRAG2Primary immunodeficiencyRecombination-activating geneT-cell receptorGeneticsLymphomaImmune systemCancer researchGeneImmunologyT cell

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.981
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0000.000
Science and technology studies0.0010.002
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.350
Teacher spread0.300 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations149
Published2014
Admission routes2
Has abstractno

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