Natural History and Clinical Behavior of Crohn's Disease Extending Beyond Two Decades
Bibliographic record
Abstract
Crohn's disease is a heterogeneous inflammatory disorder characterized by strictures or perforating complications. Information on natural history is limited. In the present study, 150 patients with long-standing Crohn's disease, including 81 females and 69 males, were seen continuously by a single clinician for at least 20 years. Additional retrospective data were available extending for >40 years and 13 have now died, usually with an advanced malignancy. To evaluate disease expression, phenotypic clinical characteristics defined by the 1998 Vienna classification for Crohn's disease were used and included age at diagnosis, location of disease, and disease behavior at the time of diagnosis or 10 years or 20 years after diagnosis. Most patients were initially diagnosed before the age of 40 years (94%) and had ileocolonic disease (65.3%). At diagnosis, both females and males were most often classified with inflammatory disease (nonstenosing, nonpenetrating); however, over the course of the disease, particularly in the first decade, decreased numbers of patients with inflammatory disease and increased numbers with penetrating disease were seen. In addition, some with stenosing disease eventually developed penetrating disease. Disease localized to ileum alone was most often complicated by stricture formation, whereas ileocolonic disease was usually complicated by a penetrating complication. This shift in disease behavior indicates that Crohn's disease is a dynamic process that phenotypically evolves and progresses with time.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".