Mini Review: Smooth Muscle Pharmacology of Substance P
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Substance P (SP), some of its C-terminal fragments and some of its homologues (physalaemin and eledoisin) are hypotensive in rats anaesthetised with urethane, vasodilators in isolated rabbit hearts, inhibitors of noradrenaline-induced contractions of the dog carotid artery and stimulants of contractions of the rabbit mesenteric vein, the guinea pig ileum and the rat colon. The effects of these peptides appear to be due to a direct action, mediated by specific receptors, in 4 of the 6 preparations, while the stimulation of the guinea pig ileum may depend in part on the release of intramural acetylcholine, because it is partially antagonised by atropine, and catecholamines appear to interfere with the contractile response of the rat colon to SP, since this response is potentiated by propranolol. SP, its C-terminal fragments, physalaemin and eledoisin appear to activate the same receptors systems in 4 of the 5 preparations in which desensitisation experiments could be performed (namely the rat blood pressure, the isolated rabbit heart, the rabbit mesenteric vein and the guinea pig ileum). In the dog carotid artery, there was no cross-desensitisation between SP and eledoisin but only between SP, its C-terminal fragments and physalaemin. The rat colon could not be desensitised.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.002 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.003 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.010 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it