RETRACTED ARTICLE: The Breast Cancer Susceptibility Gene Product Fibroblast Growth Factor Receptor 2 Serves as a Scaffold for Regulation of NF-κB Signaling
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Post-publication record
- Nature
- Retraction
- Reason
- Investigation by Company/Institution;Investigation by Journal/Publisher;Misconduct - Official Investigation(s) and/or Finding(s);
- Date
- 7/30/2018 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Fibroblast growth factor (FGF) receptor 2 (FGFR2) has been identified in genome-wide association studies to be associated with increased breast cancer risk; however, its mechanism of action remains unclear. Here we show that the two major FGFR2 alternatively spliced isoforms, FGFR2-IIIb and FGFR2-IIIc, interact with IκB kinase β and its downstream target, NF-κB. FGFR2 inhibits nuclear RelA/p65 NF-κB translocation and activity and reduces expression of dependent transcripts, including interleukin-6. These interactions result in diminished STAT3 phosphorylation and reduced breast cancer cell growth, motility, and invasiveness. FGFR2 also arrests the epithelial cell-to-mesenchymal cell transition (EMT), resulting in attenuated neoplastic growth in orthotopic xenografts of breast cancer cells. Our studies provide strong evidence for the protective effects of FGFR2 on tumor progression. We propose that FGFR2 serves as a scaffold for multiple components of the NF-κB signaling complex. Through these interactions, FGFR2 isoforms can respond to tissue-specific FGF signals to modulate epithelial cell-stromal cell communications in cancer progression.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Molecular and Cellular Biology
- Topic
- Fibroblast Growth Factor Research
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University Health NetworkUniversity of TorontoOntario Institute for Cancer Research
- Funders
- Canadian Institutes of Health Research
- Keywords
- BiologyFibroblast growth factor receptor 2Cancer researchFibroblast growth factorStromal cellFibroblast growth factor receptorSignal transductionCell growthEpithelial–mesenchymal transitionCell biologyCancerReceptorGeneticsMetastasis
- Has abstract in OpenAlex
- yes