Glomerular Basement Membrane in Experimental Nephrosis: Chemical Composition
Bibliographic record
Abstract
Basement membrane prepared by ultrasonic vibration of isolated glomeruli was obtained from normal rats and from rats with anti-kidney serum nephrosis. The membrane was found to contain collagen, lipids, and at least two glycopeptides which were separable by chromatography on Seρhadex-G75 after removal of collagen by collagenase. Sialic acid was associated with collagen and with one of the glycopeptides. Acid hydrolysis released all the sialic acid in a dialyzable form. Neuraminidase released the same amount of sialic acid but only half was dialyzable, indicating that the remainder was not present in a terminal position. Nephrotic membrane contained less phospholipid and acetyl than normal, but the same amount of collagen, hexosamine and sialic acid. The sialic acid was liberated more readily by chemical hydrolysis, but less readily by neuraminidase than that of normal membrane; the collagen was also more readily degraded. It is concluded that in nephrosis, the amount of basement membrane material is not increased and that the membrane thickening seen microscopically, and the increased permeability, result from a change in organization at a molecular level.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".