Bibliographic record
Abstract
Preclinical testing of putative neuroprotective agents for the treatment of acute ischaemic stroke is critical in assessing their therapeutic potential. Guidelines on how preclinical development of neuroprotectants should be performed were lacking until the Stroke Therapy Academic Industry Roundtable (STAIR) published their recommendations based on lessons from previous failed clinical trials of neuroprotective agents. The STAIR recommendations seek to improve the quality of preclinical research and to ensure that the data generated will enable the selection of those agents most suitable for progression from the laboratory into clinical trials. NXY-059 is a novel free-radical trapping neuroprotectant that is being investigated for the treatment of acute ischaemic stroke. Its preclinical development has closely adhered to the stringent STAIR criteria. Data from independent studies using rodent models of transient middle cerebral artery occlusion (tMCAO) and permanent MCAO (pMCAO) show that NXY-059 reduces infarct volume, improves neurological functioning and has an extended therapeutic window (≧4 h) compared with other agents in late-stage clinical development to date. A key difference in its development compared with previous neuroprotectants is that, in accordance with STAIR criteria, its neuroprotective efficacy has been confirmed in large animal models of pMCAO. These studies in marmosets clearly demonstrate that NXY-059 reduces the functional disability arising from cerebral ischaemia. As functional outcome (rather than infarct volume) is the relevant outcome against which stroke drugs are evaluated in clinical trials, this finding is both important and encouraging. NXY-059 is currently being evaluated in Phase III trials.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".