Functionalized Carborane Complexes of the [M(CO)<sub>2</sub>(NO)]<sup>2+</sup>Core (M =<sup>99m</sup>Tc, Re): A New Class of Organometallic Probes for Correlated<i>in Vitro</i>and<i>in Vivo</i>Imaging
Bibliographic record
Abstract
Functionalized carborane complexes of the [M(CO) 2 (NO)] 2+ (M = Re, 99m Tc) core have potential utility as matched pairs of probes for correlated optical (M = Re) and scintigraphic (M = 99m Tc) imaging. A synthetic route to closo -rhenacarboranes of the type [Re(CO) 2 (NO)(RR′C 2 B 9 H 9 )] in a manner suitable for the preparation of the radioactive technetium-99m analogues has been developed, resulting in the isolation of four novel metallacarboranes [Re(CO) 2 (NO)(RR′C 2 B 9 H 9 )], which exhibit both 3,1,2 ( 6a: R = H, R′ = Bn) and 2,1,8 ( 7a: R = R′ = H; 8a: R = H, R′ = Ph; 9a: R = R′ = Bn) cage configurations. These complexes absorb strongly at 300−348 nm; 6a − 9a fluoresce weakly at ambient temperature following excitation at 300 nm ( 7a ) or ∼340 nm ( 6a, 8a / 9a ), with emission maxima ranging between 313 and 411 nm. A microwave-assisted approach was used to prepare radioactive [ 99m Tc(CO) 3 ] + -carborane complexes ( 1b − 4b ) at the tracer level. When an analogous aqueous nitrosation methodology was applied to generate dicarbonylnitroso- closo -technetacarboranes, the novel complexes 6b, 8b, and 9b were isolated in good radiochemical yields (62−79%). In aqueous solutions, slow decomposition of 6b and 8b, but not 9b was observed. To better understand this process, the radioactive 186/188 Re analogue of 8a was also prepared.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".