Functionalized Carborane Complexes of the [M(CO)<sub>2</sub>(NO)]<sup>2+</sup>Core (M =<sup>99m</sup>Tc, Re): A New Class of Organometallic Probes for Correlated<i>in Vitro</i>and<i>in Vivo</i>Imaging
Bibliographic record
Abstract
Functionalized carborane complexes of the [M(CO) 2 (NO)] 2+ (M = Re, 99m Tc) core have potential utility as matched pairs of probes for correlated optical (M = Re) and scintigraphic (M = 99m Tc) imaging. A synthetic route to closo -rhenacarboranes of the type [Re(CO) 2 (NO)(RR′C 2 B 9 H 9 )] in a manner suitable for the preparation of the radioactive technetium-99m analogues has been developed, resulting in the isolation of four novel metallacarboranes [Re(CO) 2 (NO)(RR′C 2 B 9 H 9 )], which exhibit both 3,1,2 ( 6a: R = H, R′ = Bn) and 2,1,8 ( 7a: R = R′ = H; 8a: R = H, R′ = Ph; 9a: R = R′ = Bn) cage configurations. These complexes absorb strongly at 300−348 nm; 6a − 9a fluoresce weakly at ambient temperature following excitation at 300 nm ( 7a ) or ∼340 nm ( 6a, 8a / 9a ), with emission maxima ranging between 313 and 411 nm. A microwave-assisted approach was used to prepare radioactive [ 99m Tc(CO) 3 ] + -carborane complexes ( 1b − 4b ) at the tracer level. When an analogous aqueous nitrosation methodology was applied to generate dicarbonylnitroso- closo -technetacarboranes, the novel complexes 6b, 8b, and 9b were isolated in good radiochemical yields (62−79%). In aqueous solutions, slow decomposition of 6b and 8b, but not 9b was observed. To better understand this process, the radioactive 186/188 Re analogue of 8a was also prepared.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".