Demonstration of Tumor-Associated Transplantation Antigens in Rat Mammary Tumors Induced by 7,12-Dimethylbenz(α)Anthracene
Bibliographic record
Abstract
Mammary adenocarcinoma were induced by an oral administration of 7,12-dimethylbenz(α)anthracene to Sprague-Dawley (SD) rats. Antibodies to the pooled tumor cells produced in Wistar rats were made tumor-specific by successive absorption with pooled SD red blood cells, normal mammary cells, and normal serum. Such antibodies were found to be cytotoxic to the original pooled tumor cells as well as to the pools prepared from other animals, thus suggesting the existence of antigenic cross-reactivity in such hydrocarbon-induced tumors. This activity was lost when the anti-tumor antisera were heated at 56°C for 30 min but reconstituted (although not to the original level) on addition of fresh guinea pig complement. The cytotoxic activity was found to be localized in both the IgM and IgG fractions, the former being more efficient than the latter. In addition, the tumors pretreated with specific antibody were found to be nontransplantable as compared with the 90 percent transplantability of untreated tumors.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".