Acute effects of sustained isometric knee extension on cerebral and muscle oxygenation responses
Bibliographic record
Abstract
Cerebral contra-lateral frontal lobe and the dominant vastus lateralis muscle oxygenation (Cox, Mox) and blood volume (Cbv, Mbv) were recorded simultaneously using near infrared spectroscopy (NIRS) in 12 healthy volunteers (37.4 +/- 9.9 years; 72.3 +/- 16.1 kg; 171.0 +/- 9.6 cm) during 2 min resting baseline, an isometric knee extension with the 1 RM load sustained to the point of fatigue, and 3 min recovery. The mean exercise duration was 19.1 +/- 2.6 s. During the contraction, Cox and Cbv increased systematically with no sign of levelling off until the point of fatigue. In contrast, Mox and Mbv declined continuously until the termination of exercise. Qualitative analysis of these NIRS profiles suggested that maximal isometric performance under normoxic conditions was most likely not limited by central neuronal activation, but rather, was due to factors within the exercising muscle. It is likely that depletion of intramuscular stores of high energy phosphates and oxymyoglobin, as well as the accumulation of metabolites from anaerobic pathways, were implicated in fatigue during this sustained high intensity isometric contraction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".