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Record W1999000988 · doi:10.1039/c4tx00118d

New approaches to advance the use of genetic toxicology analyses for human health risk assessment

2014· article· en· W1999000988 on OpenAlexafffund
George E. Johnson, Wout Slob, Shareen H. Doak, Mick D. Fellows, B. Bhaskar Gollapudi, Robert H. Heflich, Ben J. Rees, Lya G. Soeteman‐Hernández, Jatin R. Verma, John W. Wills, Gareth Jenkins, Paul A. White

Bibliographic record

VenueToxicology Research · 2014
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCarcinogens and Genotoxicity Assessment
Canadian institutionsHealth CanadaDiscovery Centre
FundersEngineering and Physical Sciences Research CouncilHealth CanadaNational Centre for the Replacement, Refinement and Reduction of Animals in Research
KeywordsHuman healthRisk assessmentToxicologySomatic cellRisk analysis (engineering)BiologyBiotechnologyMedicineEnvironmental healthGeneticsComputer scienceGene

Abstract

fetched live from OpenAlex

Genetic toxicology testing has a crucial role in the safety assessment of substances of societal value by reducing human exposure to potential somatic and germ cell mutagens.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.010
Threshold uncertainty score0.052

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0100.013
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0050.002
Science and technology studies0.0010.003
Scholarly communication0.0030.004
Open science0.0030.004
Research integrity0.0020.005
Insufficient payload (model declined to judge)0.0070.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.411
GPT teacher head0.489
Teacher spread0.079 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2014
Admission routes2
Has abstractyes

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