Record W1999197607 · doi:10.1093/neuonc/nos229

CLIN-NEURO/MEDICAL ONCOLOGY

2012· article· en· W1999197607 on OpenAlexaff

Chul‐Kee Park, Y.-H. Kim, J. W. Kim, T. M. Kim, Seung Hong Choi, Y. J. Kim, Byung Se Choi, Seung‐Hoon Lee, Chae‐Yong Kim, I. H. Kim, D. Z. Lee, A. Kheder, Maryann Forbes, Ian Craven, Maria Hadjivassiliou, Nicole Shonka, Anne Kessinger, Michele R. Aizenberg, Michael Weller, C Meisner, Michael Platten, Guido Nikkhah, K. Papsdorf, Magnus Sabel, Christian Braun, Guido Reifenberger, Wolfgang Wick, Daniela Alexandru, Babak Haghighi, Maria Muhonen, Marc C. Chamberlain, Ashley Sumrall, Sushma Burri, Wendy G. Brick, Arash Asher, Karina Murillo-Medina, Amancio Guerrero-Maldonado, Alejandro Juárez Ramiro, Guadalupe Cervantes-Sánchez, Aura Argentina Erazo-Valle-Solís, Víctor García-Navarro, Paul W. Sperduto, Ryan Shanley, Xianghua Luo, Norbert Kased, Penny K. Sneed, David Roberge, Samuel T. Chao, Robert J. Weil, John H. Suh, Amit Bhatt, Ashley W. Jensen, Paul D. Brown, H.A. Shih, John P. Kirkpatrick, Laurie E. Gaspar, John B. Fiveash, Veronica Chiang, Jonathan Knisely, Christina Maria Sperduto, Nancy U. Lin, Minesh P. Mehta, Mark D. Anderson, Aditya Raghunathan, Kenneth Aldape, Gregory N. Fuller, M. R. Gilbert, H. Ian Robins, M. Wang, M. R. Gilbert, A. Chakravarti, Marta Penas‐Prado, Ramesh Kumar Chaudhary, Peter J. Anderson, Heinrich Elinzano, R. A. Gilbert, Tomokazu Aoki, Tetsuya Ueba, Yoshiki Arakawa, Shin Miyatake, Toshio TSUKAHARA, Susumu Miyamoto, Kohei Nozaki, Waro Taki, M Matsutani, Sophia F. Shakur, Esther N. Bit‐Ivan, William Watkin, Hajer Farhat, Ryan Merrell, H. Zwinkels, Jan Dörr, Arend J. de Kloet, M. J. Taphoorn, C. J. Vecht, Ulrich Bogdahn, Günther Stockhammer, Anuspandana Mahapatra, Peter Hau, Bernhard Schuknecht, Martin J. van den Bent, H. Heinrichs, Shlomit Yust‐Katz, V. Liu, Morris D. Groves, V. Puduvalli, V. A. Levin, C. Conrad, H. Colman, S. Hsu, Alfred Yung, Manuela Kunz, Lena Armbruster, Niklas Thon, Nathalie Jansen, J. Lutz, Jochen Herms, Rupert Egensperger, Sabina Eigenbrod, Hans Kretzschmar, Chengfang La, J.-C. Tonn, Friedrich-Wilhelm Kreth, A. A. Brandes, E. Franceschi, R. Agati, R. Poggi, P. Dall'Occa, Marco Bartolotti, Marco Di Battista, G. Marucci, Fabio Girardi, M. Ermani, W Sherman, J. Raizer, S. Grimm, Reinhard Ruckser, Georg Tatzreiter, Wolfgang Pfisterer, G. Oberhauser, S. Honigschnabel, Fatma Aboul-Enein, Christoph Ausch, Elvira Kitzweger, W. Hruby, Christian Sebesta, R. M. Green, Emily Woyshner, B. Suchorska, Hendrik Janssen, B. Hentschel, Gabriele Poepperl, Jennifer Linn, J. C. Tonn, Bogdana Suchorska, Vera Graute, Peter Bartenstein, Bahareh Hassanzadeh, Vrya Tohidi, Danijela Levacic, J. C. Landolfi, Samuel Singer, Kevin DeBraganca, C. Grommes, A. I. Omar, Pankaj Jalan, Vijay Pandav, Slava Bekker, Macarena I. de la Fuente, Thomas Kaley, Shanshan Zhao, Xuelei Chen, Riccardo Soffietti, Michela Magistrello, Luca Bertero, Chiara Bosa, S. G. Crasto, Diego Garbossa, Ivan Lolli, Elisa Trevisan, Roberta Rudà, A. Pace, C. Carapella, Cristina Dealis, Manuela Caroli, Marina Faedi, Chiara Bomprezzi, Alissa A. Thomas, J. Dalmau, Núria Gresa‐Arribas, C. E. Fadul, Priya Kumthekar, Juan Herrada, Navya K. Antony, Michael Richards, Arpita Gupta, Mark M Landeros, Celso Arango, Angel F Campos-Gines, Paula N. Friedman, Hannah Wilson, Jessica Streeter, Aileen Cleary Cohen, Jeffrey A. Gilreath, Daniel S. Sageser, X. Ye, J McGregor, Eric C. Bourekas, R. Cavaliere, H. Newton, J. Sul, Yazmín Odia, W. Zhang, Jin‐Yuan Shih, John A. Butman, Dima A. Hammoud, T. N. Kreisl, Fábio M. Iwamoto, H. A. Fine, Luiz Gustavo Sueth Berriel, F. N. Santos, Assaf Levy, Margherita Fanelli, Ludmilla Thomé Domingos Chinen, Alessandro Costa, H. Wayne Slone, F. Bokstein, Deborah T. Blumenthal, Shulim Shpigel, L. Phishniak, Pedro Garciarena, D. Liue, Ying Yuan, Eric T. Wong, John L. Villano, Herbert H. Engelhard, Zvi Ram, Barbara‐Ann Millar, Arjun Sahgal, Normand Laperrière, Warren Mason, V. A. Levin, Kenneth R. Hess, Ali Choucair, Patrick J. Flynn, K. A. Jaeckle, Athanasios P. Kyritsis, W. K. A. Yung, M. D. Prados, J. M. Bruner, Sandra Ictech, Phioanh L. Nghiemphu, Albert Lai, Timothy F. Cloughesy, Wafik Zaky, F. Gilles, J. Grimm, Stephan Blüml, G. Dhall, Tena Rosser, Linda M. Randolph, Kathy Wong, A. Olch, Marco Aurélio Krieger, J. Finlay, Jordi Capellades, Emmanuelle Verger, Santiago Medrano, Sergio González, M. Gil, Gaspar Reynés, Teresa Ribalta, O. Gallego, P. P. Segura, H.-S. Gwak, Jin‐Deok Joo, Soojin Kim, Hyo Soon Yoo, Sang‐Hun Shin, Jiguang Han, H. T. Kim, Tae-Jin Yun, J. S. Lee, S. H. Lee, W. Kim, Michael A. Vogelbaum, M. Wang, David M. Peereboom, David R. Macdonald, C. Giannini, Jung H. Suh, Robert B. Jenkins, Nadia N. Laack, D. G. Brackman, D. C. Shrieve, Luís Souhami, Annette Leibetseder, A. Wohrer, Michael Ackerl, Birgit Flechl, Cornelia Sax, Sabine Spiegl‐Kreinecker, J. Pichler, Georg Widhalm, K. Dieckmann, Matthias Preusser, C. Marosi, Catherine L. Sebastian, M. Alvarez Alejandro, Cusenier Bernadette, Akira Naomi, P. Kavan, E. Garoufalis, Marie‐Christine Guiot, T. Muanza, Rolando F. Del Maestro, Kevin Petrecca, Rajesh Sharma, Richard Curry, Johanna A. Joyce, Marc K. Rosenblum, Edward Jaffe, Matthew J. Matasar, O. Lin, Richard I. Fisher, F. M. Iwamoto, Tyler J. Fraum, Lakshmi Nayak, Lisa M. DeAngelis, Elena Pentsova, Elizabeth Vera‐Bolanos, K. Aldape, Mary Jo Necesito-Reyes, Maryam Fouladi, Amar Gajjar, Stewart Goldman, P. Métellus, T. Mikkelsen, A. Omuro, Roger J. Packer, S. Partap, I. F. Pollack, M. Prados, H. Ian Robins, Jing Wu, Terri S. Armstrong, M. Nakada, Katsuyoshi Miyashita, Manabu Kinoshita, T. Furuta, Hussein Sabit, Derek Kita, N. Uchiyam, Kentaro Kawakami, T. Minamoto, J.-i. Hamada, M. Susan Heaney, Jorge A. Carrasquillo, Alexander Krauthammer, M. J. Gil, J. Fuster, M. Benavides, C. Mesia, Olatz Etxániz, J Canellas, X. Perez-Martin, K. Hunter, Sandra K. Johnston, Carly A. Bridge, Russell C. Rockne, Laura Guyman, Anne Baldock, Jason K. Rockhill, Maciej M. Mrugała, B. C. Beard, Jennifer E. Adair, H.-P. Kiem, Tushar Ranjan, K. B. Peters, Lloyd M. Alderson, Leighann Bailey, Horácio Friedman, James J. Vredenburgh, Brett Theeler, Benjamin Ellezam, Isaac Melguizo‐Gavilanes, N. A. Shonka, Vinay K. Puduvalli, Joe Taylor, Eoin P. Flanagan, Brian Patrick O’Neill, T. Seigal, J. Baerhing, Khê Hoang‐Xuan, Tracy T. Batchelor, Ryo Nishikawa, Filipe Pinto, Jonathan Blay, A. Korfel, D. Schiff, B. D. Fu, Xiao–Tang Kong, Daniela A. Bota, K. Beal, P. Ivy, Philip H. Gutin, Nian Wu, Sasan Karimi, H. Pentsova, Titus Chan, R Mathew, Leif A. Droms, Fumiko Shimizu, V. Tabar, S. Grossman, Susannah Yovino, Jian Campian, Aaron T. Wild, Joseph M. Herman, Malcolm V. Brock, Ani Sarkis Balmanoukian, J. Portnow, B. Badie, Timothy W. Synold, Seán Lacey, M. D'Apuzzo, P. Frankel, M. Chen, Karen S. Aboody, Nathalie Letarte, Michael Gabay, Linda R. Bressler, Joan M Stachnik, S. K. Anderson, A Willson, Alvaro Moreno‐Aspitia, Gerardo Colón‐Otero, Tushar Patel, Edith A. Perez, D. A. Reardon, J. E. Herndon, April Coan, Frances McSherry, Eric Lipp, Alise Brickhouse, William A. Massey, A. Desjardins, Mary Welch, M. Westphal, Francis Bach, Daniel A. Reuter, Michael Ronellenfitsch, J. Steinbach, Torsten Pietsch, James A. Connelly, M Hamza, Maxwell L. Neal, A. D. Trister, Sunyoung Ahn, Jessica Lange, A. Baldock, A. Lai, Alexander Neuwelt, Tiffany Nguyen, Rose Marie Tyson, M. Nasseri, Edward A. Neuwelt, Joseph Bubalo, P. D. Barnes, S. Phuphanich, Jim C. Hu, Jeremy Rudnick, Ran Chu, Jian Yu, Rika Naruse, Julia Y. Ljubimova, C. Sánchez, Anne Cristine Guevarra, Rebecca Naor, Keith L. Black, Ali Mahta, Tapan Bhavsar, Kanchana Herath, C. Huang, JL McClain, Kathryn Rizzo, J. Sheehan, Michael Glantz, M. J. Glantz, Christina Zoccoli, Melissa Nicholas, Tongxin Xie, Daniel White, S. Liker, Thomas F. Gajewski, Julia M. Selfridge, David Piccioni, Mira Zurayk, Rajen Mody, Jun Quan, S. Li, W. Chen, Arthur P. Chou, Linda M. Liau, R. Green, V. Gomez-Molinar, Sergio Ruíz-González, Rafael Ricardo Valdez‐Vázquez, Óscar Arrieta, J. I. Stenner

Bibliographic record

VenueNeuro-Oncology · 2012

Typearticle

Languageen

FieldMedicine

TopicCancer Treatment and Pharmacology

Canadian institutionsUniversité de MontréalMontreal Neurological Institute and HospitalWestern UniversityMcGill University

Fundersnot available

KeywordsMedicineInternal medicineOncologyMedical physics

DOI10.1093/neuonc/nos229

Abstract

fetched live from OpenAlex

PURPOSE: This study was performed to evaluate the incidence of seizures with its implications on disease progression and the diagnostic value of post-ictal magnetic resonance images (MRI) during the management of highgrade gliomas (HGGs). PATIENTS AND METHODS: A total of 406 consecutive patients with newly diagnosed HGGs were retrospectively reviewed. The incidence of seizure attacks during the management was investigated. In patients who experienced a seizure, the causality between seizures and disease progression was assessed by pre-ictal, post-ictal (,1 month), and follow-up (,3 months) MRI. RESULTS: After a mean follow-up of 21.9 months (range, 0.1 -88.3), seizure attacks developed in 127 patients (31%). Of the 127 patients, radiological progression at the post-ictal MRI was found in 83 patients (65%) and the follow-up MRI confirmed progression in 79 patients (62%). However, other 4 patients (3%) were shown to be progression-free. Among those without radiological progression at the post-ictal MRI, the follow-up MRI confirmed progression-free in 31 patients (24%); however, 13 patients (10%) revealed eventual progression. In the patients with a seizure, absence of preoperative seizure (p 0.003), , 95% tumor resection (p 0.001), and pre-ictal Karnofski Performance Scale score 70 (p 0.025) were significantly associated with disease progression. CONCLUSION: During the management of HGG, 31% of patients experienced seizures; of these patients, 72% harbored progressive disease. The post-ictal MRI is useful for detecting disease progression; however, there are pitfalls. Clinical settings should be considered together for diagnosing disease progression in patients with seizures.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001

metaresearch head score (Gemma)0.001

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)

Consensus categoriesInsufficient payload (model declined to judge)

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Not applicable · Consensus signal: Not applicable

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.499

Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.001	0.001
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.001	0.000
Bibliometrics	0.000	0.000
Science and technology studies	0.000	0.000
Scholarly communication	0.000	0.000
Open science	0.000	0.000
Research integrity	0.001	0.001
Insufficient payload (model declined to judge)	0.008	0.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052

GPT teacher head0.412

Teacher spread0.359 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Insufficient payload (model declined to judge)

Study designNot applicable

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2

Published2012

Admission routes1

Has abstractyes

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