Immunoreactive Parathyroid Hormone and in vitro Inhibition of Erythropoiesis by Uremic Serum in Patients on Continuous Ambulatory Peritoneal Dialysis
Bibliographic record
Abstract
Inhibition of erythropoiesis in vitro by uremic serum is well established. The role of parathyroid hormone (PTH) as inhibitor of erythropoiesis is uncertain. To further elucidate this effect we correlated the in vitro growth of red cell progenitors (BFU-E) in the presence of uremic serum from 26 patients on continuous ambulatory peritoneal dialysis with levels of immunoreactive PTH in the serum. The patients had a mean hemoglobin level of 100 +/- 20.1 g/l. The BFU-E growth was 98.8 +/- 28.3% of control. No correlation between BFU-E growth and hemoglobin was found. A significant negative correlation between levels of immunoreactive PTH and BFU-E growth was found (p = 0.05). These results support the notion that PTH or PTH fragment(s) might be responsible for the in vitro inhibition of erythropoiesis by uremic serum in patients on continuous ambulatory peritoneal dialysis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".