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Record W1999690368 · doi:10.1038/ng.1017

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

2011· review· en· W1999690368 on OpenAlexaff
Lavinia Paternoster, Marie Standl, Chih‐Mei Chen, Adaikalavan Ramasamy, Klaus Bønnelykke, Liesbeth Duijts, Manuel A. R. Ferreira, Alexessander Couto Alves, Jacob P. Thyssen, Eva Albrecht, Hansjörg Baurecht, Bjarke Feenstra, Patrick Sleiman, Pirro G. Hysi, Nicole M. Warrington, Ivan Curjuric, Ronny Myhre, John A. Curtin, Maria M. Groen‐Blokhuis, Marjan Kerkhof, Annika Sääf, André Franke, David Ellinghaus, Regina Fölster‐Holst, Emmanouil T. Dermitzakis, Stephen B. Montgomery, Holger Prokisch, Katharina Heim, Anna‐Liisa Hartikainen, Anneli Pouta, Juha Pekkanen, Alexandra I. F. Blakemore, Jessica L. Buxton, Marika Kaakinen, Pamela A. F. Madden, Andrew C. Heath, Grant W. Montgomery, Philip J. Thompson, Melanie C. Matheson, Peter N. Le Souëf, Beaté St Pourcain, George Davey Smith, John Henderson, John P. Kemp, Nicholas J. Timpson, Panos Deloukas, Susan M. Ring, H‐Erich Wichmann, Martina Müller‐Nurasyid, Natalija Novak, Norman Klopp, Elke Rodríguez, Wendy L. McArdle, Allan Linneberg, Torkil Menné, Ellen A. Nøhr, Albert Hofman, André G. Uitterlinden, Cornelia M. van Duijn, Fernando Rivadeneira, Johan C. de Jongste, Ralf J.P. van der Valk, Matthias Wjst, Rain Jögi, Frank Geller, Heather A. Boyd, Jeffrey C. Murray, Cecilia Kim, Frank Mentch, Michael March, Massimo Mangino, Tim D. Spector, Véronique Bataille, Craig E. Pennell, Patrick G. Holt, Peter D. Sly, Carla M. T. Tiesler, Elisabeth Thiering, Thomas Illig, Medea Imboden, Wenche Nystad, Angela Simpson, Jouke‐Jan Hottenga, Dirkje S. Postma, Gerard H. Koppelman, Henriëtte A. Smit, Cilla Söderhäll, Bo Chawes, Eskil Kreiner‐Møller, Hans Bisgaard, Erik Melén, Dorret I. Boomsma, Adnan Čustović, Bo Jacobsson, Nicole Probst‐Hensch, Lyle J. Palmer, Daniel Glass, Håkon Håkonarson, Mads Melbye, Deborah Jarvis, Vincent W. V. Jaddoe, Christian Gieger, David P. Strachan, Nicholas G. Martin, Marjo‐Riitta Järvelin, Joachim Heinrich, David M. Evans

Bibliographic record

VenueNature Genetics · 2011
Typereview
Languageen
FieldMedicine
TopicDermatology and Skin Diseases
Canadian institutionsUniversity of TorontoOntario Institute for Cancer Research
FundersNational Institute on Alcohol Abuse and AlcoholismNational Institute on Drug AbuseLundbeckfondenWellcome Trust
KeywordsBiologyAtopic dermatitisGenome-wide association studyGeneticsGenetic associationComputational biologySingle-nucleotide polymorphismGeneImmunologyGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0020.003
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.104
GPT teacher head0.371
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations351
Published2011
Admission routes1
Has abstractno

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