Transpubertal Modulation of Pituitary and Testicular Function in the ob/ob Mouse
Why this work is in the frame
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Bibliographic record
Abstract
We have investigated developmental, transpubertal, changes in the responsiveness to stimulation of pituitary gland and testes from the male ob/ob mouse. These organs were removed from ob/ob mice at 33 and 90 days after birth and stimulated with GnRH and LH, respectively, in vitro. Pituitary glands from lean mice released significantly more LH than those from ob/ob mice at both ages. In contrast, FSH release was higher in young ob/ob mice but not significantly different at 90 days when compared with lean controls. LH-stimulated testes revealed that although the young ob/ob testes released significantly less testosterone (T) than lean controls, the response became normal after the time of expected puberty. The production of 5 alpha-androstane-3 alpha, 17 beta-diol (DIOL), although reduced at both ages in ob/ob mice, declined transpubertally in both lean and ob/ob mice. As a result, the ratio of T:DIOL which normally becomes much greater than 1 with the advent of puberty, also increases to greater than 1 in the ob/ob males, suggesting that sexual maturation of testicular androgen biosynthesis is approximately normal. We conclude that the differences in pituitary and testicular response to stimulation could arise from a defect in the ability of the pituitary gland to release gonadotrophins.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it