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Dysfunctional HDL containing L159R ApoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice

2011· article· en· 21 citations· W2000703690 on OpenAlex· 10.1016/j.bbalip.2011.08.019

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

The three-model screen

all 1,000 screened works →

All three models called this out of scope.

stratum: fund_new · design weight: 1678.90 (the sample is stratified; any rate computed without the weight is wrong)
Claude Opus 4.8OUT
genre: empirical
about Canada: no
confidence: high

Lipid biology of dysfunctional HDL in atherosclerosis; abstract absent but the title is unambiguous.

GPT-5.6 (high)OUT
genre: empirical
about Canada: no
confidence: high

It studies lipid biology and atherosclerosis in hyperlipidemic mice.

Grok 4.5OUT
genre: empirical
about Canada: no
confidence: high

Title is clear domain atherosclerosis/lipid research despite missing abstract.

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Topic
Cholesterol and Lipid Metabolism
Field
Medicine
Canadian institutions
Funders
National Center for Research ResourcesNational Heart, Lung, and Blood InstituteGladstone InstitutesNational Cancer InstituteNational Institutes of HealthWake Forest UniversityUniversity of British ColumbiaNorth Carolina Biotechnology Center
Keywords
Dysfunctional familyExacerbationInternal medicineMedicineCardiologyPsychiatry
Has abstract in OpenAlex
no