An Acute Infusion of Lactic Acid Lowers the Concentration of Potassium in Arterial Plasma by Inducing a Shift of Potassium into Cells of the Liver in Fed Rats
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
<b><i>Background:</i></b> Potassium (K<sup>+</sup>) input occurs after meals or during ischemic exercise and is accompanied by a high concentration of <i>L</i>-lactate in plasma (P<sub>L-lactate</sub>). <b><i>Methods:</i></b> We examined whether infusing 100 µmol <i>L</i>-lactic acid/min for 15 min would lead to a fall in the arterial plasma K<sup>+</sup> concentration (P<sub>K</sub>). We also aimed to evaluate the mechanisms involved in normal rats compared with rats with acute hyperkalemia caused by a shift of K<sup>+</sup> from cells or a positive K<sup>+</sup> balance. <b><i>Results:</i></b> There was a significant fall in P<sub>K</sub> in normal rats (0.25 m<i>M</i>) and a larger fall in P<sub>K</sub> in both models of acute hyperkalemia (0.6 m<i>M</i>) when the P<sub>L-lactate</sub> rose. The arterial P<sub>K</sub> increased by 0.8 m<i>M</i> (p < 0.05) 7 min after stopping this infusion despite a 2-fold rise in the concentration of insulin in arterial plasma (P<sub>Insulin</sub>). There was a significant uptake of K<sup>+</sup> by the liver, but not by skeletal muscle. In rats pretreated with somatostatin, P<sub>Insulin</sub> was low and infusing <i>L</i>-lactic acid failed to lower the P<sub>K</sub>. <b><i>Conclusions:</i></b> A rise in the P<sub>L-lactate</sub> in portal venous blood led to a fall in the P<sub>K</sub> and insulin was permissive. Absorption of glucose by the Na<sup>+</sup>-linked glucose transporter permits enterocytes to produce enough ADP to augment aerobic glycolysis, raising the P<sub>L-lactate</sub> in the portal vein to prevent postprandial hyperkalemia.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it