MétaCan
Menu
Back to cohort
Record W2001175105 · doi:10.1002/ijc.27438

Self‐reported history of infections and the risk of non‐Hodgkin lymphoma: An InterLymph pooled analysis

2012· article· en· W2001175105 on OpenAlexafffund
Nikolaus Becker, Michael O. Falster, Claire M. Vajdic, Silvia de Sanjosé, Otoniel Martı́nez-Maza, Paige M. Bracci, Mads Melbye, Karin E. Smedby, Eric A. Engels, Jennifer Turner, Paolo Vineis, Adele Seniori Costantini, Elizabeth A. Holly, John J. Spinelli, Carlo La Vecchia, Tongzhang Zheng, Brian C.‐H. Chiu, Maurizio Montella, Pierluigi Cocco, Marc Maynadié, Lenka Foretová, Anthony Staines, Paul Brennan, Scott Davis, Richard K. Severson, James R. Cerhan, Elizabeth C. Breen, Brenda M. Birmann, Wendy Cozen, Andrew E. Grulich, Robert Newton

Bibliographic record

VenueInternational Journal of Cancer · 2012
Typearticle
Languageen
FieldMedicine
TopicLymphoma Diagnosis and Treatment
Canadian institutionsBC Cancer Agency
FundersMedical Research CouncilUniversity of California, San FranciscoNational Cancer InstituteNational Institutes of HealthBundesamt für StrahlenschutzCancerfondenFondation de FranceNational Health and Medical Research CouncilEuropean CommissionCanadian Institutes of Health ResearchCompagnia di San Paolo
KeywordsLymphomaHodgkin lymphomaMedicineInternal medicineOncology

Abstract

fetched live from OpenAlex

We performed a pooled analysis of data on self-reported history of infections in relation to the risk of non-Hodgkin lymphoma (NHL) from 17 case-control studies that included 12,585 cases and 15,416 controls aged 16-96 years at recruitment. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were estimated in two-stage random-effect or joint fixed-effect models, adjusting for age, sex and study centre. Data from the 2 years before diagnosis (or date of interview for controls) were excluded. A self-reported history of infectious mononucleosis was associated with an excess risk of NHL (OR = 1.26, 95% CI = 1.01-1.57 based on data from 16 studies); study-specific results indicate significant (I(2) = 51%, p = 0.01) heterogeneity. A self-reported history of measles or whooping cough was associated with an approximate 15% reduction in risk. History of other infection was not associated with NHL. We find little clear evidence of an association between NHL risk and infection although the limitations of data based on self-reported medical history (particularly of childhood illness reported by older people) are well recognized.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.024
metaresearch head score (Gemma)0.037
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.024
Threshold uncertainty score0.128

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0240.037
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0090.032
Bibliometrics0.0080.006
Science and technology studies0.0000.000
Scholarly communication0.0030.001
Open science0.0020.002
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.305
Teacher spread0.294 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations27
Published2012
Admission routes2
Has abstractyes

Explore more

Same venueInternational Journal of CancerSame topicLymphoma Diagnosis and TreatmentFrench-language works237,207