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Record W2001428037 · doi:10.1073/pnas.0708504105

Adaptation increases the likelihood of diversification in an experimental bacterial lineage

2008· article· en· W2001428037 on OpenAlexaff
Christine C. Spencer, Jabus Tyerman, Melanie Bertrand, Michael Doebeli

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicEvolution and Genetic Dynamics
Canadian institutionsUniversity of British Columbia
FundersJames S. McDonnell Foundation
KeywordsBiologyLineage (genetic)Evolutionary biologyDiversification (marketing strategy)EcologyAdaptation (eye)Experimental evolutionFitness landscapeLocal adaptationNicheGeneticsGenePopulationDemography

Abstract

fetched live from OpenAlex

Understanding the mechanisms and processes that generate biological diversity is a fundamental problem in evolution and ecology. In the past decade, the theory of evolutionary branching and adaptive diversification has provided new perspectives for understanding the evolution of diversity caused by ecological interactions. In models of adaptive diversification, the fitness landscapes change dynamically, so that the likelihood of diversification into different phenotypic clusters increases over time. In contrast, in models with static fitness landscapes, the likelihood of diversification decreases as populations climb fitness peaks, because crossing maladaptive fitness valleys becomes increasingly difficult. We used experimental evolution in bacteria to test how the likelihood of diversification changes over time in a bacterial lineage that has diversified in sympatry from a single ancestral strain. By analyzing the "fossil" record of this lineage, and restarting the lineage from different time points in the evolutionary past, we demonstrate that: (i) the lineage has initially undergone a phase of directional adaptation to the competitive environment, and (ii) during this phase, the likelihood of diversification increases significantly over time. These results suggest evolutionary branching caused by frequency-dependent competition as the main mechanism of diversification in our experimental populations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.219
Threshold uncertainty score0.170

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.038
GPT teacher head0.295
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations70
Published2008
Admission routes1
Has abstractyes

Explore more

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