Localization and partial characterization of a molecule found in the plasma membrane of starfish and sea urchin embryos using a novel monoclonal antibody
Bibliographic record
Abstract
A monoclonal antibody, P212, has been developed which reacts against 120 kD and 90 kD proteins, P212 antigens found in the plasma membranes of both starfish and sea urchin embryos. Immunocytochemical studies with colloidal gold tagged P212 showed that the P212 antigens are also found on the inner membranes of several different types of granules and vesicles located in the eggs and cytoplasm of embryonic cells, and in the trans region of the Golgi apparatus. One or both of the P212 antigens are also found in the cortical granules, granules which are exocytosed at fertilization. They are not found on intracellular membrane structures such as the rough endoplasmic reticulum, the nuclear membrane, or a number of deeper granular structures. The P212 antigens are probably located on the membranes of vesicles which are on the exocytosis-endocytosis pathway and may be involved in cell trafficking.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".