Wasted salts and wasted bodies: new insight into the role of claudin 7 in the kidney
Bibliographic record
Abstract
IN MULTICELLULAR ORGANISMS, epithelial sheets function as a barrier between two compartments via their ability to form tight junctions (TJs), which regulate the diffusion of fluid, electrolytes, and small molecules through the paracellular path-way. Members of the relatively recently described Claudin (Cldn) family of integral membrane proteins, with at least 23 distinct members in mammals, are the major structural and functional components of TJ strands and are considered to be the best candidates for forming paracellular channels (3, 4, 6, 15). Similarities and differences between Cldn family members and their diverse expression patterns are thought to provide the molecular basis for the hetereogeneous features of the paracel-lular permeability barriers, including differences in the degree of “tightness ” and ion selectivity, manifested in different tis-sues and organs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".