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Record W2002288604 · doi:10.1007/s10969-011-9114-2

The success of structural genomics

2011· article· en· W2002288604 on OpenAlexaboutno aff
Thomas C. Terwilliger

Bibliographic record

VenueJournal of Structural and Functional Genomics · 2011
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Bioinformatics, and Biomedical Research
Canadian institutionsnot available
Fundersnot available
KeywordsStructural genomicsGenomicsComputational biologyGenome BiologyFunctional genomicsData scienceBiologyComputer scienceGenomeGeneticsProtein structureGeneBiochemistry

Abstract

fetched live from OpenAlex

The International Conference on Structural Genomics (ICSG 2011, http://sgc.utoronto.ca/ICSG2011/index.php ) [corrected], held in Toronto Canada May 10-14, 2011 was a rich and exciting demonstration of how far structural genomics has come. Structural genomics has now matured into a field that includes both structure and the biology that structure enables. This has allowed targeting based on systematic approaches and on known biological importance and allows biochemical studies to be closely tied to structure determination. The wealth of purified proteins, clones, and chemical probes produced by structural genomics groups will enable a vast amount of follow-on research. The technologies, the structures, and the biology that were described at the meeting were at the cutting edge of science. Structural genomics has become a success.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.015
metaresearch head score (Gemma)0.015
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.015
Threshold uncertainty score0.079

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0150.015
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0020.006
Scholarly communication0.0040.007
Open science0.0020.003
Research integrity0.0030.008
Insufficient payload (model declined to judge)0.0070.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.244
Teacher spread0.222 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations20
Published2011
Admission routes1
Has abstractyes

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