<i>Trypanosoma congolense</i> infections: MHC class II‐restricted immune responses mediate either protection or disease, depending on IL‐10 function
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
BALB/c mice are highly susceptible and C57BL/6 relatively resistant to Trypanosoma congolense infections. Here we show that relatively resistant wild-type B6 mice infected with T. congolense survive significantly longer (> 200 days) than infected major histocompatibility complex (MHC) class II-deficient B6 mice (approximately 50 days). We also show that blocking of the interleukin-10 (IL-10) receptor induces early death of wild-type B6 mice infected with T. congolense (approximately 10 days), but does not affect the survival of infected MHC class II-deficient B6 mice. We conclude that MHC class II-restricted immune responses mediate protection and, when IL-10 function is impaired, MHC class II-restricted immune responses mediate early mortality in otherwise resistant B6 mice. Thus, in T. congolense infections, MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it