Corticosterone Increases Depression-Like Behavior, With Some Effects on Predator Odor-Induced Defensive Behavior, in Male and Female Rats.
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Bibliographic record
Abstract
This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats. Rats received either corticosterone or vehicle injections for 21 consecutive days prior to behavioral testing in the forced swim, open-field, and predator odor tests. The corticosterone injections significantly increased depression-like behavior in the forced swim test in both male and female rats but had no significant effect on anxiety in the open-field test. In the predator odor test, the corticosterone injections significantly increased a subset of defensive behaviors in the male rats. These results suggest that repeated exposure to corticosterone increases depression-like behavior, with some effects on anxiety, and that male rats may be more affected than female rats by this manipulation.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it