Abstract 1979: Tripartite motif 14 (TRIM14) is a putative tumor suppressor gene in non-small-cell lung cancer.
Bibliographic record
Abstract
Abstract Background: Non-small-cell lung carcinoma (NSCLC) accounts for 85% of all malignant lung tumors. Our group previously identified Tripartite Motif 14 (TRIM14) as a component of a prognostic multigene expression signature for NSCLC patients. TRIM14 belongs to a conserved family of Tripartite Motif-encoding genes that are involved in a broad range of biological processes, such as transcriptional regulation, cell proliferation, and apoptosis. However, TRIM14 itself is poorly understood, especially in the context of cancer progression. Here we investigate the biological function of TRIM14 in NSCLC. Methods: The expression of TRIM14 was modified in human NSCLC cell lines (NCI-H1395, NCI-H1650 and NCI-H157) by lentivirus-mediated overexpression and short-hairpin RNA-mediated silencing. Effects were assessed by examining in vitro cell proliferation and anchorage-independent growth, and in vivo tumorigenicity in mice. Results: In vitro studies show that TRIM14 overexpression in NSCLC cells suppresses proliferation and anchorage-independent growth, whereas knock-down of TRIM14 expression promotes cell proliferation and colony formation. In vivo studies demonstrate that knock-down of TRIM14 expression significantly increases tumor growth in immunodeficient mice. Conclusion: This is the first study to suggest that TRIM14 may function as a tumor suppressor gene in lung cancer, affecting cell proliferation and anchorage-independent growth in vitro and tumor growth in mice. (Supported by Canadian Cancer Society Research Institute grant #020527) Citation Format: Josephine Hai, Ming-Sound Tsao. Tripartite motif 14 (TRIM14) is a putative tumor suppressor gene in non-small-cell lung cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1979. doi:10.1158/1538-7445.AM2013-1979
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.008 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".