Automated 2D–3D registration of portal images and CT data using line‐segment enhancement
Bibliographic record
Abstract
In prostate radiotherapy, setup errors with respect to the patient's bony anatomy can be reduced by aligning 2D megavoltage (MV) portal images acquired during treatment to a reference 3D kilovoltage (kV) CT acquired for treatment planning purposes. The purpose of this study was to evaluate a fully automated 2D-3D registration algorithm to quantify setup errors in 3D through the alignment of line-enhanced portal images and digitally reconstructed radiographs computed from the CT. The line-enhanced images were obtained by correlating the images with a filter bank of short line segments, or "sticks" at different orientations. The proposed methods were validated on (1) accurately collected gold-standard data consisting of a 3D kV cone-beam CT scan of an anthropomorphic phantom of the pelvis and 2D MV portal images in the anterior-posterior (AP) view acquired at 15 different poses and (2) a conventional 3D kV CT scan and weekly 2D MV AP portal images of a patient over 8 weeks. The mean (and standard deviation) of the absolute registration error for rotations around the right-lateral (RL), inferior-superior (IS), and posterior-anterior (PA) axes were 0.212 degree (0.214 degree), 0.055 degree (0.033 degree) and 0.041 degree (0.039 degree), respectively. The corresponding registration errors for translations along the RL, IS, and PA axes were 0.161 (0.131) mm, 0.096 (0.033) mm, and 0.612 (0.485) mm. The mean (and standard deviation) of the total registration error was 0.778 (0.543) mm. Registration on the patient images was successful in all eight cases as determined visually. The results indicate that it is feasible to automatically enhance features in MV portal images of the pelvis for use within a completely automated 2D-3D registration framework for the accurate determination of patient setup errors. They also indicate that it is feasible to estimate all six transformation parameters from a 3D CT of the pelvis and a single portal image in the AP view.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".