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Record W2003877144 · doi:10.1159/000214034

Discrepant Platelet Kinetic Data Obtained in Rats Using the Platelet Labels <sup>51</sup> Cr and DFP <sup>3</sup> H

2009· article· en· W2003877144 on OpenAlexaff
A D Ginsburg, Richard H. Aster

Bibliographic record

VenuePathophysiology of Haemostasis and Thrombosis · 2009
Typearticle
Languageen
FieldMedicine
TopicAntibiotics Pharmacokinetics and Efficacy
Canadian institutionsQueen's University
Fundersnot available
KeywordsPlateletChemistryKineticsIsotopeRadiochemistryPlatelet activationNuclear chemistryInternal medicinePhysics

Abstract

fetched live from OpenAlex

Platelet kinetics in a single species, the rat, have been studied utilizing two different labels – 51Cr, and DFP 3H. Disappearance of isotope was primarily linear with time with the 51Cr tag, but exponential with DFP 3H. This difference could not be ascribed to a toxic effect of the DFP or its carrier, propylene glycol, or to nonuniform uptake of the labels by platelets of differing mean age. It is suggested, therefore, that DFP is preferentially lost from the platelet either by elution or by release of a platelet component to which this isotope binds. The possibility is discussed that such loss is concerned with platelet function, perhaps in support of endothelial integrity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.654
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.063
GPT teacher head0.335
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2009
Admission routes1
Has abstractyes

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