Expression of Nuclear Orphan Receptors Ngfi-B/Tr3, Nurr1 And Nor-1 after Global Brain Ischemia in Rat
Bibliographic record
Abstract
INTRODUCTION. Neuron-derived orphan receptor (NOR-1) was cloned from cultured embryonal neurons undergoing apoptotic cell death. NOR-1 is related to the nuclear orphan receptors, NGFI-B and NURR1, which interact with the retinoic acid receptor, RXR. NGFI-B and NURR1 are immediate early genes in the ischemic brain, suggesting a role in repair or cell death. Very recently, NGFI-B/TR3 was found to exert a pro-apoptotic effect through mitochondrial targeting and cytochrome release leading to apoptosis (1). Such dual role of NGFI-B (and related orphans) in nuclear and mitochondrial function could be important for neuronal damage in brain ischemia (stroke). We evaluated novel gene expression (mRNA levels) of nuclear orphan receptors after short brain ischemia. This model allows to correlate changes in gene and protein expression with pathological outcome, i.e. selective vulnerability occurs in CA1 neurons of the hippocampus while the adjacent CA3 cells and the dentate granule cells survive.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".