Effect of Prostaglandin-E <sub>2</sub> on Gastric Secretion and on Gastric Circulation of Totally Isolated ex vivo Canine Stomach
Bibliographic record
Abstract
Totally isolated canine stomachs, perfused with homologous blood, were used for the study of the effect of prostaglandin-E<sub>2</sub> (PGE<sub>2</sub>) on gastric secretion and circulation. Ex vivo stomachs were stimulated by a constant infusion of histamine into the gastric artery. When histamine-induced secretion was stabilized, PGE<sub>2</sub> was introduced intra-arterially for 1 h. Doses of PGE<sub>2 </sub>tested were 500, 250 and 125 µg/h. After 1 h PGE<sub>2</sub> infusion was interrupted, but histamine stimulation continued. PGE<sub>2</sub> significantly inhibited the output of gastric juice, HCl and pepsin and reduced the concentration of HCl. The effect of PGE<sub>2</sub> was still very marked after it was discontinued. PGE<sub>2</sub> had a potent vasodilator action on gastric circulation: it reduced the gastric peripheral resistance and the gastric arterial perfusion pressure. This hemodynamic action of PGE<sub>2</sub> was present only during infusion of the inhibitor.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".