Effect of Prostaglandin-E <sub>2</sub> on Gastric Secretion and on Gastric Circulation of Totally Isolated ex vivo Canine Stomach
Bibliographic record
Abstract
Totally isolated canine stomachs, perfused with homologous blood, were used for the study of the effect of prostaglandin-E2 (PGE2) on gastric secretion and circulation. Ex vivo stomachs were stimulated by a constant infusion of histamine into the gastric artery. When histamine-induced secretion was stabilized, PGE2 was introduced intra-arterially for 1 h. Doses of PGE2 tested were 500, 250 and 125 µg/h. After 1 h PGE2 infusion was interrupted, but histamine stimulation continued. PGE2 significantly inhibited the output of gastric juice, HCl and pepsin and reduced the concentration of HCl. The effect of PGE2 was still very marked after it was discontinued. PGE2 had a potent vasodilator action on gastric circulation: it reduced the gastric peripheral resistance and the gastric arterial perfusion pressure. This hemodynamic action of PGE2 was present only during infusion of the inhibitor.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".