Lipid mediators in membrane rafts are important determinants of human health and disease
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The new field of membrane rafts has provided fresh insight and a novel framework in which to understand the interaction, relation, and organization of lipids and proteins within cell membranes. This review will examine our current understanding of membrane rafts and their role in human health. In addition, the effect of various lipids, including dietary lipids, on membrane raft structure and function will be discussed. Membrane rafts are found in all cells and are characterized by their high concentration of cholesterol, sphingolipids, and saturated fatty acids. These lipids impart lateral segregation of membrane proteins, thus facilitating the spatial organization and regulation of membrane proteins involved in many cellular processes, such as cell proliferation, apoptosis, and cell signaling. Therefore, membrane rafts are shedding new light on the origins of metabolic disturbances and diseases such as cancer, insulin resistance, inflammation, cardiovascular disease, and Alzheimer's disease, which will be further discussed in this review.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it