Raised Plasma Adenosine Associated with Chronic Fatigue Syndrome
Bibliographic record
Abstract
Plasma adenosine levels were measured in a small trial study of eighteen volunteers, aged 36-85 years. Volunteers comprised nine with chronic fatigue syndrome (CFS), four with ‘other fatigue’ illnesses, and five with no history of fatigue illnesses but some of whom were related to chronic fatigue sufferers. Plasma adenosine was slightly raised above the minimum detectable level (approx. 1 micromole/L) in one healthy non-fatigued volunteer and grossly raised (greater than 5 micromoles/L) in two non-fatigued volunteers, both of whom were related to CFSs. Among the nine CFSs, all had plasma adenosine raised above baseline, and seven were grossly raised. High adenosine levels were also seen in two of the volunteers with ‘other fatigue.’ Raised adenosine occurred among certain families, suggesting a genetic metabolic element. Instability of adenosine in frozen stored plasma was noted. High levels of adenosine probably do not exist freely within peripheral plasma but may be released from blood cells locally within tissues or in response to venipuncture stress or other factors. The results may be highly relevant to other pathologies such as heart disease.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".