Descriptive analysis of timing of administration of antimicrobial therapy for septic shock in a medical–surgical intensive care unit
Bibliographic record
Abstract
Background:Septic shock remains a major cause of morbidity and mortality in intensive care units worldwide. According to the guidelines of the Society of Critical Care Medicine, antimicrobial therapy should be initiated within the first hour after recognition of severe sepsis. Furthermore, initiation of antibiotic administration within this timeframe has been associated with better survival to hospital discharge among adult patients, whereas survival declined with delays beyond 1 hour. We undertook this study to evaluate the timing of administration of antibiotics in relation to diagnosis of septic shock in an 11-bed medical—surgical intensive care unit (ICU) within a community hospital to compare the findings with international guidelines and best evidence.Methods:We performed a retrospective chart audit for adult patients (>18 years of age) with septic shock who were admitted to the Burnaby Hospital medical—surgical ICU between January and June 2006. We extracted from each chart the time of initiation o...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".