Measuring neuronal branching patterns using model-based approach
Why this work is in the frame
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Bibliographic record
Abstract
Neurons have complex branching systems which allow them to communicate with thousands of other neurons. Thus understanding neuronal geometry is clearly important for determining connectivity within the network and how this shapes neuronal function. One of the difficulties in uncovering relationships between neuronal shape and its function is the problem of quantifying complex neuronal geometry. Even by using multiple measures such as: dendritic length, distribution of segments, direction of branches, etc, a description of three dimensional neuronal embedding remains incomplete. To help alleviate this problem, here we propose a new measure, a shape diffusiveness index (SDI), to quantify spatial relations between branches at the local and global scale. It was shown that growth of neuronal trees can be modeled by using diffusion limited aggregation (DLA) process. By measuring "how easy" it is to reproduce the analyzed shape by using the DLA algorithm it can be measured how "diffusive" is that shape. Intuitively, "diffusiveness" measures how tree-like is a given shape. For example shapes like an oak tree will have high values of SDI. This measure is capturing an important feature of dendritic tree geometry, which is difficult to assess with other measures. This approach also presents a paradigm shift from well-defined deterministic measures to model-based measures, which estimate how well a model with specific properties can account for features of analyzed shape.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it