Spontaneous Long-term Smoking Cessation in a Patient With Schizophrenia After Treatment With Ziprasidone
Bibliographic record
Abstract
A patient suffering from schizophrenia stopped smoking 9 days after the initiation of treatment with ziprasidone and had not resumed smoking 2 years later. While a reduction in cigarette consumption has been previously observed after the switch from typical to atypical antipsychotics, spontaneous cessation of smoking has not been previously reported during treatment with ziprasidone. Cigarette smoking is very common in patients with schizophrenia, and it is a major cause of morbidity and mortality in this group. Any treatment that assists these patients to stop smoking is thus of great value. The relationships between schizophrenia, smoking, and antipsychotic medication are complex. In the context of a brief but comprehensive literature review, we discuss potential explanations for the successful outcome seen in our patient.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".