Interaction of hydroxyphenyl alkyl ketones with β-cyclodextrin
Bibliographic record
Abstract
Binding constants of β-cyclodextrin with six hydroxyphenyl alkyl ketones having a general structure Z-Ph-CO-(CH 2 ) n CH 3 (Z = o-OH or p-OH and n = 0, 1, or 3) were measured at 25°C by UV-vis spectrophotometry. In all cases the formation of 1:1 host-guest complexes was established. NMR chemically induced shifts indicated mixed complexation modes. Equilibrium constants are around 200 M -1 for some of the compounds and for the others around 1000 M -1 . It is suggested that complexes with different geometries coexist in the solution with predominance of those with the aryl group (K SCD [Formula: see text] 200 M -1 ) or alkyl group (K SCD [Formula: see text] 1000 M -1 ) inside the cavity.Key words: inclusion complex, β-cyclodextrin, hydroxyphenyl alkyl ketones, association constants, UV-vis spectrophotometry.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.008 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".