Re-analysis of genome wide data on mammalian microRNA-mediated suppression of gene expression
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
microRNAs are short endogenously expressed RNAs that regulate gene expression post-transcriptionally. Although both mRNA degradation and suppression of mRNA translation can mediate reduced protein levels following microRNA targeting of an mRNA, their relative contributions have remained elusive. A recent genome-wide study in mammals employing RNA-sequencing to measure microRNA effects on mRNA translation and stability concluded that 84-89% of microRNA-induced suppression of gene expression is due to degradation of target mRNAs. We re-analyzed this data set and applied a number of analysis modifications which revealed that the contribution of mRNA translation was likely underestimated for some mRNA subsets. Moreover, in contrast to the original analysis, our analysis indicated that suppression of mRNA translation precedes mRNA degradation upon microRNA targeting. Our findings thereby enhance our understanding of microRNA mediated genome wide suppression of gene expression in mammals.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it